2018 Scientific Research Initiative Grantees

Investigator: Steve Broglio
Website: concussion.umich.edu

concussion graphicConcussion (mild traumatic brain injury) is a major public health concern facing the medical community and society at large in the United States and worldwide. In many ways, concussion research is in its infancy relative to moderate and severe brain injury, with substantial gaps in our fundamental understanding of injury prevention, pathophysiology, diagnostics, management, outcomes, and financial impact. With support of the Biosciences Initiative, 24 faculty and staff from 13 distinct University of Michigan units have joined to form The Michigan Concussion Center. This center will provide the necessary infrastructure to advance concussion knowledge and health care by implementing a multi-disciplinary approach that advances patient health. Researchers will conduct multi-disciplinary research answering fundamental questions on concussion injury prevention, pathophysiology, diagnostics, management, outcomes, and financial impact.

Michigan Concussion Center grantee presentation

Grantee PI Steve Broglio presents at the 2018 BSI Kickoff.

The center’s structure revolves around three cores with distinct, yet mutually supportive functions: 1) the Research Core; 2) the Clinical Core; and 3) the Outreach & Translation Core. The vision of The Michigan Concussion Center is to become an international leader in concussion research, care, and education by unifying diverse faculty from across the University of Michigan to advance patient health by conducting multi-disciplinary research. The center will approach its research endeavors in a way that translates laboratory, clinic, and community observations into interventions intended to reduce concussion risk and improve outcomes in those affected by the injury.

Learn more from the executive summary.
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Investigators: Allen Burton, Ines Ibanez, Allison Steiner, Knute Nadelhoffer
Website: seas.umich.edu/research/centers_institutes/global_change_biology/mission

Global change biology seeks to understand the biosphere’s responses to human activities, including: climate shifts, land-use conversion, release of pollutants, and species introductions. Although organisms have modified the earth’s climate in the past, current human activities are exerting an unprecedented impact on the rate of environmental change. These environmental challenges are complex and difficult to approach; simply identifying the trends or organisms’ responses to stressors is not enough. Research needs to shift towards generating forecasts that combine changes, impacts, and responses to assist science-based decision making relevant to society.

Institute for Global Change Biology grantee presentation

Grantee PI Allen Burton presents at the 2018 BSI Kickoff.

The Institute for Global Change Biology will answer this need by fostering research to understand and forecast the interactive effects of global change drivers on organisms and ecosystems. The mission for the institute is to: 1) understand the effects of global change biology; 2) develop decision-making frameworks; 3) identify forecast indicators; 4) develop forecast models; and 5) focus on issues that inform decision-makers. The Biosciences Initiative support serves as a planning grant to launch the program and create the institute; a larger, more comprehensive program is expected to follow.

Learn more from the executive summary.
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Investigators: David Sherman, Ashootosh Tripathi
Website: lsi.umich.edu/science/centers-technologies/natural-products-discovery-core

Academic drug discovery is a crucial enterprise at research intensive universities, and these efforts have been expanding at the University of Michigan over the past 15 years. Not only does this work facilitate the drive to identify new disease targets, train the next generation of scientists and support basic research, but it also offers a fantastic opportunity to build sustainable funding sources through licensing of technology and high value molecules. Access to small molecules that offer potential to generate strong composition of matter intellectual property is a cornerstone of a sustainable drug discovery program.

Natural Products Discovery grantee presentation

Grantee PI David Sherman presents at the 2018 BSI Kickoff.

The Expanding Natural Product Drug Discovery at the University of Michigan Biosciences Synergy Initiative is positioned to expand and fill important gaps in an already unique strength at Michigan: its one-of-a-kind natural products drug discovery capabilities. To do so, this program will add three new faculty hires to accommodate and synergize in the field of natural product sciences and build a state-of-the-art Natural Products Discovery Core in the Life Sciences Institute. These additions will provide effective, responsive, and high value access to new chemical matter, positioned readily for downstream transformation into unique, bioactive, patentable small molecules with high potential for development into effective therapeutics against a broad range of human diseases.

Learn more from the executive summary.
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Investigators: Melanie Ohi, Janet Smith, Michael Cianfrocco
Website: lsi.sites.uofmhosting.net/science/centers-technologies/cryo-electron-microscopy

Structural biology uncovers the details of biological materials, proteins and other macromolecules, connecting their form and function. Determining the relationship between their shape at an atomic level and their cellular function provides insights into molecular mechanisms that impact human health and disease. The classic example of the impact of structural biology is the discovery of the structure of DNA by Franklin, Crick, and Watson, which immediately explained how DNA encodes information and suggested a model of inheritance.

The Future of Cryo-EM at U-M grantee presentation

Grantee PI Melanie Ohi presents at the 2018 BSI Kickoff.

Funding from the Bioscience Initiative will allow the University of Michigan to invest in: (1) using new cryo-EM technologies to visualize molecular machines inside intact cells, (2) solving systemic bottlenecks in the cryo-EM “sample-to-structure” pipeline, and (3) becoming a leading international site for education of new cryo-EM practitioners. This cryo-EM initiative draws on a combination of strong partnerships with departments, schools, and core facilities across campus and with industry to position U-M at the forefront of this rapidly evolving field, to allow U-M researchers to embrace the current “resolution revolution” in cryo-EM, and to make U-M an international leader and premier destination for cryo-EM education.

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June 16 – 20: Cryo-EM Workshop 2019: “I have my data set – now what?”

Investigators: Nils Walter, Mats Ljungman
Website: umichrna.org

Revolutionary discoveries in the biosciences recently have revealed that ribonucleic acid (RNA) is critical for most aspects of human health, and that its misregulation is responsible for many diseases. Recent research shows that the range of cellular RNAs has expanded to include short and long non-coding RNAs. Although discoveries uncovering their full functions in human physiology are only beginning to emerge, it’s already understood that these short and long non-coding RNAs profoundly impact all cellular processes, from stem cell differentiation to cancer. These revelations provide an unprecedented opportunity to invest in advanced studies of RNA as a gateway to precision medicine.

RNA Biomedicine grantee presentation

Grantee PI Nils Walter presents at the 2018 BSI Kickoff.

Emerging in parallel are revolutionary new technologies for RNA analysis, ranging from single molecule microscopy and next-generation sequencing to genome editing, ushering in an abundant era of both discovery research and medical translation in RNA biomedicine that is beginning to go “viral.” In response to these opportunities, a grassroots effort of unmatched proportions – involving approximately 150 faculty from across campus – began in 2016 to move the University of Michigan toward a leadership position in the biosciences by forming the nascent Center for RNA Biomedicine (CRB). We will now leverage the enthusiasm, energy and synergy of this emergent movement by creating a comprehensive Biosciences Scientific Research Initiative in RNA, enacting multiple foundational faculty hires and implementing innovative campus-wide resources, with the goal of establishing Michigan as a world leader in RNA biomedicine.

Learn more from the executive summary.
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